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PROSIT Disease Modelling Community

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PROSIT is an international scientific open source development community for health economic disease models in medicine. prosit [latin] = "it shall be useful"

Aim of this development community is to provide valid and lasting open source disease models for chronic diseases such as diabetes. Disease models for relevant late complications of diabetes mellitus (i.e. nephropathy, retinopathy, diabetic foot syndrome, stroke, myocardial infarction) have been developed. The future mission is to integrate also models for other chronic diseases such as asthma, COPD and more.

RANDI2

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RANDI2 is an open source web application for randomization within clinical trials. It supports a variety of randomization algorithms and offers a very useful set of functions for randomization data & progress visualization and trial management - for more information please visit http://www.randi2.org

IHE open source

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This project holds an implementation of the Cross-Enterprise Document Sharing (XDS) profile as defined by IHE (ihe.net). It includes implementations of both the Document Registry and Document Repository actors.

The project is deployed at the XDS Public Registry Test Facility of the National Institute of Standards and Technology (NIST).

rxncon

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The complexity of cellular networks is an outstanding challenge for documentation, visualisation and mathematical modelling. In this project, we develop a new way to describe these networks that minimises the combinatorial complexity and allows an automatic visualisation and export of mathematical (ODE/rulebased) models.

Features:

  • Automatic visualiztion with Cytoscape.
  • Automatic generation of rule based models for BioNetGen.
  • Storage of biological facts that can be used for modelling.

Simulation Open Framework Architecture (SOFA)

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SOFA is an Open Source framework primarily targeted at real-time simulation, with an emphasis on medical simulation. It is mostly intended for the research community to help develop newer algorithms, but can also be used as an efficient prototyping tool.

HL7v3 Test Harness

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"The HL7 Test Harness system is an HL7 v3 message conformance testing application that also provides the ability to simulate the message processing actions of a client and/or server system. The app provides message workflow, format and content testing."

ODIN

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"ODIN is a C++ software framework to develop, simulate and run magnetic resonance sequences on different platforms."

CTSim

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CTSim simulates the process of transmitting X-rays through phantom objects. These X-ray data are called projections. CTSim reconstructs the original phantom image from the projections using a variety of algorithms. Additionally, CTSim has a wide array of image analysis and image processing functions.

GIMIAS

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GIMIAS is a workflow-oriented environment for solving advanced biomedical image computing and individualized simulation problems, which is extensible through the development of problem-specific plug-ins. In addition, GIMIAS provides an open source framework for efficient development of research and clinical software prototypes integrating contributions from the Physiome community while allowing business-friendly technology transfer and commercial product development.

GIMIAS suites are collections of prototypes that build a complete platform for one or more clinical applications.

i2b2

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i2b2 (Informatics for Integrating Biology and the Bedside) is an NIH-funded National Center for Biomedical Computing based at Partners HealthCare System. The i2b2 Center is developing a scalable informatics framework that will enable clinical researchers to use existing clinical data for discovery research and, when combined with IRB-approved genomic data, facilitate the design of targeted therapies for individual patients with diseases having genetic origins. This platform currently enjoys wide international adoption by the CTSA network, academic health centers, and industry.

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