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TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.

Submitted by holger on Tue, 2013/12/17 - 08:33
TitleTSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.
Publication TypeJournal Article
Year of Publication2012
AuthorsDietrich, JW, Landgrafe, G, Fotiadou, EH
JournalJ Thyroid Res
Volume2012
Pagination351864
Date Published2012
ISSN2042-0072
Abstract

This paper provides the reader with an overview of our current knowledge of hypothalamic-pituitary-thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical components of this complex relationship. Integrating these data into a systems perspective delivers new insights into static and dynamic behaviour of thyroid homeostasis. Explicit usage of this information with mathematical methods promises to deliver a better understanding of thyrotropic feedback control and new options for personalised diagnosis of thyroid dysfunction and targeted therapy, also by permitting a new perspective on the conundrum of the TSH reference range.

DOI10.1155/2012/351864
Alternate JournalJ Thyroid Res
PubMed ID23365787
PubMed Central IDPMC3544290
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